Manam

Nagarjuna Akkineni

Nageswar Rao / Seetharamudu / Bittu

Nageshwara Rao Akkineni

Chaitanya

Naga Chaitanya Akkineni

Nagarjuna / Radha Mohan

Shriya Saran

Rama Lakshmi / Anjali

Samantha Ruth Prabhu

Krishna Veni / Priya

Brahmanandam

Girish Karnad

Ali Basha

Leonardo DiCaprio

Posani Krishna Murali

Inspector Dharma

Jayaprakash Reddy

Home Minister J.P.

Shankar Melkote

Yashwanth Rayudu

Saranya Ponvannan

Seetharamudu's Mother

Satya Krishnan

Lecturer

Tejaswi Madivada

Divya

M. S. Narayana

Father Francis

Duvvasi Mohan

Home Minister's Assistant

Gundu Sudarshan

Marriage Broker

Saptagiri

Nagarjuna's Friend

Krishnudu

Doctor

Srinivasa Reddy

Car Broker

Chalapathi Rao

Merchant

Amitabh Bachchan

Pratap (Special Appearance)

Amala Akkineni

Dance Teacher (Special Appearance)

Akhil Akkineni

Akhil (Special Appearance)

Neetu Chandra

Air Hostess (Special Appearance)

Raashii Khanna

Prema (Special Appearance)

Lavanya Tripathi

Radha Mohan's Friend (Special Appearance)